Dextromethorphan is a potent anti-tussive agent having low bio availability of 11%. The present research investigation was to prepare Polymeric micelles containing Dextromethorphan, nanotechnology-based drug delivery systems that enhance the solubility using different grades of Pluronic’s F-68, F-188, F-407 respectively by solvent evaporation method. The Polymeric micelles so prepared were characterized for its particle size, Zeta potential, PDI, TEM analysis, Drug loading efficiency. Among various formulations PM9 showed greater drug loading efficiency i.e 90% and particle size of 50nm that will be further formulated into Oral Dispersible tablets using different super disintegrants like SSG, Cross povidone, Low- HPC, among various formulations F9 showed less disintegration time of 10 sec and maximum drug release of 98.89%. from the kinetic observations of optimized formulation F9, R2of release data based on best curve-fitting method for selected ODT the drug release showed First order kinetics i.e R2= 0.869 indicating that the drug release depends upon its concentration.