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ISSN 2063-5346
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Formulation and Evaluation of Diclofenac Potassium Emulgel using Essential Oils for the Pain Management in Arthritis

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MohitMahajan, Dr.VaibhavVaidya, RohitJadhav, PrachiFarande, Shrutika Bhagde, Abhishek Galgate
» doi: 10.48047/ecb/2023.12.si12.043

Abstract

This study aims to formulate & evaluate Diclofenac Potassium Emulgel using different essential oils for managing pain in arthritis. Emulgel is an effective drug delivery system for delivering of hydrophobic drugs. Diclofenac Potassium is a BCS class-II drug & a NSAID (Non-steroidal Anti-inflammatory drug) used for anti-pyretic, analgesic and anti- inflammatory activity. Topical delivery has many advantages over oral dosage forms hence have more patient compliance and effective treatment. Different essential oils like Turmeric oil, Clove oil and Peppermint oil were used as a penetration enhancer. Different formulations were prepared and evaluated on their physical appearance, phase separation, pH, viscosity, spreadability, globule size, zeta potential and In-vitro drug release test. Compatibility study was done by using Fourier-Transform Infrared (FTIR) Spectrometer. All the formulations were found to be acceptable on parameters such as physical properties like color, homogeneity and consistency, grittiness, spreadability, pH and viscosity. After 8hrs. of In-vitro diffusion study, FC2 batch containing 8% of Clove oil showed highest drug release i.e. 72.87% and appropriate viscosity. Therefore conclusion can be drawn out that the prepared emulgel formulation can be helpful and effective in relief from joints pain and arthritis.

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