The emergence of the fast-dissolving drug delivery system stemmed from the desire to offer patients a more convenient method for taking medication. Many individuals find it challenging to swallow tablets and hard gelatin capsules. The primary aim of this research was to develop a consistent formulation for fast-dissolving tablets of Diclofenac sodium, a therapeutic molecule already in use. The objective was to improve its effectiveness while avoiding side effects such as gastric irritation. Various batches of tablets were formulated using the direct compression method, incorporating different concentrations of natural super disintegrants Ocimum sanctum seed powder. The study examined the impact of altering the natural super disintegrant and its concentration on the formulation. The optimized batches were compared to determine the most effective super disintegrants for the Diclofenac sodium Fast-dissolving tablets (FDT) formulation. The tablets underwent evaluation for hardness, thickness, drug content, friability, weight variation, in-vitro disintegrating time study, and in-vitro drug release study.