Fungus is one of the most frequent causes of skin conditions, and the prevalence of infectious illnesses is expanding worldwide. While oral treatment of parasitic disease has been linked to deadly impact, long duration of treatment, and narrow-mindedness by the patient, topical treatment for superficial contagious contaminations has been linked to poor medicine dissolvability, irritating to skin, and reduced penetrability via skin. In order to improve medication entrance, decrease drug reactions, and give quick symptomatic relief from parasite infections, solid lipid nanoparticles carrying antifungal medicines were developed. In the current investigation, the medication Efinaconazole-loaded micro molecules were put into the aloe Vera gel matrix to increase the drug's penetration into the skin. The anti-fungal drug's solid lipid Nano molecules were created. The solid lipid Nano molecules of (SLN-EFINACONAZOLE) are made using the solvent emulsification method, which increases the efficacy of drug trapping and continuous distribution. The original source is the "Portal of Health Products & Essential Medicine" of the WHO.