This research focused on the formulation and evaluation of fast dissolving oral film containing extracts of ocimum sanctum and glycyrrhiza glabra to treat mouth ulcer. The extracts of ocimum sanctum and glycyrrhiza glabra was formulated as films by solvent casting method using various polymers viz. HPMC E5, HPMC E15, Sodium alginate and Polyvinyl alcohol. Propylene glycol was used to create the films as a plasticizer, sodium starch glycolate as a super disintegrate, and honey as a sweentner. Furthermore, the films are evaluated for thickness, weight variation, folding endurance, surface pH, percentage moisture uptake, percentage moisture loss, disintegration time, in vitro drug release study and stability study. The extracts of both ocimum sanctum and glycyrrhiza glabra was collected by maceration process. The phytoconstituents study of the extract revealed the presence of alkaloids, flavonoids, tannins, steroids and saponins. The extracts were formulated into films by solvent casting method with various polymers such as HPMC E5, HPMC E15, sodium alginate and polyvinyl alcohol. The idea of a quick-dissolving dose form has gained popularity as a new delivery method. By reducing dosing frequency, this approach will give better bioavailability and optimal stability. It will also avoid first pass metabolism of the medicines. From the above results it is evident that the developed formulation can be an innovative dosage form to improve the drug delivery, onset of action. Additionally, it will increase patient compliance.