Diltiazem is a calcium channel blocker used in the management of hypertension and angina pectoris. The purpose of this research work was to formulate a fast dissolving film of Diltiazem for the treatment of hypertension, by using polymers such as HPMC E15 and Polyethylene Glycol 400 in different concentrations. Films of Diltiazem were prepared by solvent casting method using polymers in different ratios. Polyethylene Glycol 400 was used as a plasticizer. Films were subjected to physicochemical characterization such as thickness, weight uniformity, folding endurance, drug content, surface pH study, in vitro drug release, and stability studies. Films were found to be satisfactory when evaluated for thickness, weight uniformity, in-vitro drug release, folding endurance, drug content and disintegration time. The surface pH of all the films was found to be neutral. The optimized formulation F5 also showed satisfactory pH, drug content (99.63%),),effective in vitro drug release (96.65%), disintegration time of 32.45 seconds and satisfactory stability.