The emphasis of present work was to modify the drug release characteristics by solvent evaporation method using polymer such as EudragitRL100 and ethyl cellulose. The prepared microsphere was characterized by FTIR, DSC and calculated for size of particle analysis, DEE, and in-vitro delivery. FTIR studies showed no potential chemical interaction between the drug and polymers. Calculated percent yield for all the formulations were found to be in range of 71.01 to 96.00% and the size in range of 28.00 to 51.00μm. Gastrointestinal fluid (SGF) for Half day used to the drug release study and shown extreme amount of drug release in controlled and sustained manner to extended period of time. The in-vitro drug release study was performed using dissolution rate test apparatus in phosphate buffer (pH 7.4). The dissolution profiles of Fluvastatin are given in Tables 6, Tables 7 and Table 8. 74.12, 73.12, 71.76, 68.12, 71.18, 73.01, 74.09, 75.92 and 70.07% drug was released from K1, K2, K3, K4, K5, K6, K7, K8 and K9 formulations respectively. The DSC study indicated that drug uniformly dispersed in amorphous state in molecular level. Non-ficain transport has been followed Drug released mechanism.