Utilising gelling ingredients including HPMC, Sodium Alginate, and Sodium Carboxymethylcellulose, the Nitazoxanide oral In situ gel F1, F2, F3, F4, F5, and F6 was created. FT-IR spectroscopy was used to conduct a chemical compatibility analysis, and the results showed that there was no change in the principal peaks, indicating that there was no interaction between the medicine and excipients. Nitazoxanide's calibration curve was created in simulated stomach juice with a pH of 1.2. Six different nitazoxanide formulations In situ gel was prepared using varying concentrations of different polymers such as HPMC, Sodium Alginate and Sodium Carboxymethylcellulose as the release retardants