In this study, pioglitazone gastroretentive mucoadhesive tablets were designed to improve gastric residence time and overall bioavailability. Different mucoadhesive polymers such as HPMC K200 M, Na CMC, Carbopol 974P, gum karaya, chitosan and xanthan gum were selected for the production of tablets. Various formulations have been prepared using polymers at different concentrations. The repose angle, bulk density, tap speed, Carr index and Hausner ratio of the pioglitazone mucoadhesive tablet pre-compressed mixture were characterized and the results showed that the mixture had better flow and hence better performance. Swelling studies were performed on the formulations and the results showed a good swelling index for all formulations. Drug release studies show that the formulation releases the drug in a first-class sequence. Therefore, according to the results, the RF13 formula was seen to be an optimized formulation