Gynecological disorders are very common in women and are due to many factors which may include weak immune system, imbalance in body hormones, high sugar intake in food, regular or frequent use of antibiotics, improper hygiene, physical/mental stress, some microbial infections. , bacteria and yeasts cause fungal or other major infections of the delicate female genitalia. According to Ayurvedic literature, many herbs are used to treat female disorders, although proper documentation and validation needs to be established. One of the main fungi that cause vaginal candidiasis infections is Candida species. It deserves more and more special attention in the medical community. Despite the presence of Candida species as human communicators, alarming rates of local and systemic infections have been observed, varying from moderate to severe effects. The present work aimed to formulate and evaluate herbal cream containing hydro-alcoholic extract of Ipomea cairica Linn. The extracts of the root of selected plant was used to make herbal cream and was compared with a standard anti-fungal drug formulation. The results showed that the prepared herbal cream showed superior and significant antifungal activity. More studies need to be established to deepen the knowledge on this field focusing on clinical trials to provide safer and more effective anti-fungal than the current studies widely used to treat vaginal candidiasis.