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ISSN 2063-5346
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Formulation And Evaluation Of Immediate Release Tablets Of Anti-Hypertensive Drug Using Natural Gum

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Satyam Mishra, Sunil kumar Yadav, Dr. Manish Kumar Gupta
» doi: 10.31838/ecb/2023.12.si7.311

Abstract

The objective of designing animmediate release tablet to provide a convenient and user-friendly alternative to traditional oral dosage forms such as tablets using natural gum. Immediate release tablets, also known as orally disintegrating tablets (ODTs) or quick-dissolving tablets, are formulated to disintegrate rapidly in the mouth without the need for water or chewing, allowing for easy administration and improved patient compliance. The tablets were prepared by direct compression method using natural gum such as Plantago ovate gum (PG), Fenugreek seed gum (FG) were used in tablet formulation. The prepared formulation were evaluated for various physical parameters, in-vitro drug release profile and stability study. The formulation PGNF4 gives faster dissolution 98.53%, within 20 minutes whereas the FGNF4 fenugreek mucilage as superdisintegrant was showed highest dissolution 81.91%, within 20 minutes. The optimized PGNF4 immediate release tablet batch showed no change in physical appearance, drug content or in dissolution pattern for 90 days under the stability study. Finally it was concluded that batch PGNF4 containing formulation showed highest drug release in lesser time and both of selected natural gum successfully can be used for the development of immediate release tablet in future. It can be used as super disintegrating agent.

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