A sustained release system for Losartan Potassium designed to increase its residence time in the stomach without contact with the Microspheres was achieved through the preparation of floating Microspheres by the Modified Emulsion solvent Diffusion method. In the present study attempt has been made to develop sustained released drug delivery system by formulating the floating Microspheres of Losartan Potassium using psyllium husk powder as a natural polymer which is biodegradable, biocompatible, nontoxic, economically cheap cost, devoid of adverse and side effects and easily availability. Losartan Potassium chemically 1 cyclopropyl-6-fluoro-8- methoxy-7- (3-methylamino piperidine -1- yl)-4- oxoquinoline-3- carboxalic acid used as an Anti-hypertensive agent. The 12 batches of floating Microspheres (LF1 to LF12) were formulated by Modified Emulsion solvent Diffusion method using different ratio of polymers like Psyllium husk power, HPMC K4M and Carbopal. The formulated Microspheres were evaluated by means of different parameters like shape and density of Microsphere, drug content uniformity, Invitro buoyancy, swelling Index, Invitro dissolution studies. The formulation LF5 has better sustained release when compared other formulations, hence we conclude that the combination of Psyllium husk powder, HPMC K4M shows better Gastric retention time which sustains the release of the dosage form