Diabetes mellitus is the metabolic disorder that obstruct the normal step of wound healing.Metformin hydrochloride having anticoagulant, anti-inflammatory and anti proliferative effect that could affect wound healing or risk of wound complication after surgery or injury. The objective of the present study was to develop formulation of metformin hydrochloride in different gel including hydroalcoholic ,hydrogel ,microemulsion, anhydrous gel and alcoholic gel bases. The result shows that all gel formulation showed good and acceptable physical properties. The obtained data from release study revealed that the total amount of drug release was affected the nature ofthe basewith maximum drug release wasalcoholic>hydrogel >hydroalcoholic>anhydrous >microemulsion gel base. Statistical analysis resulting that the higher release rate of the first three gel bases was significant when it compare to the anhydrous and microemulsion gel bases.The result of the different chemical and physical test of metformin hcl gel showed that the formation could be used topically in order to protect skin damage and these formulation for better absorption and penetration of the active moiety into the systemic circulation. In this different gelling agent can be used to formulate topical gel of metformin hydrochloride for long term stability study as per ich guidelines.