Alopecia means hair loss, today 70% males and 30% females are suffering from this disorder. The need for a suitable topical delivery system which would increase the contact time, leading to increase in local drug concentration of Minoxidil for the treatment of alopecia led to the development of topical gel formulation .Minoxidil has a half life of 4.2 hrs and a melting point of 2480C. It enhances the hair growth by increasing the blood flow to the scalp by vasodilatation. The Preformulation studies like FTIR and solubility were conducted; Trans dermal gels were prepared using HPMC and carbopol in different ratios. Ethanol and transcutol were used as solvents and permeation enhancers; glycofural is used to compare the permeation capacity. The prepared gels were evaluated for the PH, drug content, viscosity, invitro diffusion studies, Ex vivo permeation studies, drug release kinetics and stability studies. The formulation containing 1600mg of HPMC and 10% transcutol showed better drug release and was found to follow non-Fickian release mechanism, it was found to be stable when compared to the marketed formulation-Tugain2%.