In the current investigation, the Antihistaminic drug desloratadine is formulated into a mouth dissolving film (MDF) for immediate drug release, enhanced therapeutic efficacy, and enhanced patient compliance. Batch processing with indion 204 resins was used to taste masking; complexes were tuned with respect to processing duration, pH, temperature, and drug-resin ratio. Resins indion-234 effectively covered the taste. and determined that a drug-resin ratio of 1:1, a pH of 7, and a temperature of 30°C within 3 hours resulted in the most effective drug loading. MDF and were then prepared using the optimized resinate. The rapid medication delivery was achieved by combining the medicine with polymers like HPMC E-5 and HPMC E-15 in the mouth dissolving film. The plasticizer PEG 400 was used in a solvent casting process to create a film that dissolves in the mouth. Disintegration time, film thickness, and folding endurance were investigated as response variables; a 32 -level complete factorial design was used to optimize the influence of independent factors such as HPMC E-5 and HPMC E-15. Using design of expert software, we examined the answers and discovered that HPMC E-5 and HPMC E-15 concentrations had large effects on the dependent variables. Maximum dissolving rate (99.02 0.284%) and minimal disintegration time (10 Sec) were observed for the developed optimized formulation & UV and FTIR spectrophotometry were used to identify drug excipient interaction.