The main objective of the present research work was to establish the mouth dissolving tablet of Ketorolac Tromethamine for the management of moderate to severe pain that may get caused after Dental Procedures. The drug excipient compatibility was evaluated by Fourier transform .Infrared Spectroscopy (FTIR). It confirmed that there is no interaction between the drug and excipients used. The MDT were prepared using Direct Compression Method by using various natural and synthetic superdisintegrant such as Crosspovidone, Crosscarmellose, Modified Agar and Banana Powder. The formulation batches of mouth dissolving tablet of Ketorolac Tromethamine were designed by employing different Superdisintegrants. All Superdisintegrants were used alone and in combination at various concentrations; and were taken to see the combination effect