The objective behind this research work was to formulate & evaluate mouth dissolving tablets of Levamisole Hydrochloride to improve patient compliance during administration, give faster onset of action and improve bio-availability. Levamisole Hydrochloride is class I anthelmintic drug and it is also used as immunostimulant and anti-neoplastic agent. Bitter taste of Levamisole Hydrochloride was masked and mouth dissolving tablet formulation were prepared by using excipient Sodium Starch Glycolate, Mannitol, Sucrose, et using direct compression method. The prepared tablets were evaluated forthickness, uniformity of weight, hardness, friability, disintegration, dissolution and drug content. Optimised batch was found to comply all parameters of specifications