A wound is an injury to the skin or to any other portion of the bodily tissues. According to recent estimates, 6 million individuals globally experience chronic wounds. Topical antibiotics are frequently used in clinical settings for wounds, cuts, and burns due to their possible role in localised cutaneous infections. This study aimed to formulate and evaluate a nanoemulgel using a Box-Behnken design with Garcinia indica extract, focusing on its wound healing activity. The nanoemulgel was developed to enhance the delivery and efficacy of Garcinia indica extract for wound healing applications. Box-Behnken design was employed to optimize the formulation variables, including the concentration of Garcinia indica extract, oil phase-to-aqueous phase ratio, and emulsifier concentration. The prepared nanoemulgel was characterized for various parameters such as particle size, polydispersity zeta potential, viscosity, and drug content. The in vitro release study was conducted to assess the release pattern of the extract from the nanoemulgel. The wound healing activity of the optimized nanoemulgel was evaluated using an excision wound model in rats. Wound healinhg activity was checked by assessing various parameters in rats. Results showed that For the group IV where rats received application of 1.0% nanoemulgel of Garcinia indica extract it was observed that on 16th day the wound area shrunk upto 9.5± 1.98 mm2. For the group IV which were treated with 1 % nanoemulgel of Garcinia indica the tensile strength was observed to be 199.85± 10.50 grams which is very appreciable. The developed nanoemulgel using the Box-Behnken design exhibited favorable physicochemical properties and demonstrated significant wound healing activity. The nanoemulgel formulation could serve as a promising approach for enhancing the delivery and therapeutic efficacy of Garcinia indica extract in wound healing applications. Further studies are warranted to explore the underlying mechanisms and conduct clinical trials to validate its effectiveness in human subjects.