Psoriasis is a chronic inflammatory skin disease that attack the immune system. Isoliquiritigenin is one of the most important bioactive compound derived from licorice root. However, its therapeutic use is restricted due to its poor aqueous solubility and limited bioavailability. To overcome these limitations, a novel ILG-loaded nanoliposomes (ILG-NL) is designed. The aim of the present study was to evaluate the nanoliposomes containing isoliquiritigenin for its anti- psoriatic action. The different polymers at various ratios were used to formulate the formulations. The formulations were prepared by injection method. The prepared formulations were evaluated for different parameters including particle size, PDI, zeta potential, drug loading and entrapment efficiency. After primary evaluation formulations F3 was selected for further studies including drug release, HRTEM and antipsoriatic potential. The nanoliposome (F3) was found to be superior in the in-vitro release testing and possess better antipsoriatic potential.