Given that Silybum marinum seed extract is a medication with limited solubility, the goal of the current work was to develop oral soluble films of Silybum marinum seed extract to maximize patient convenience during administration, give faster onset of action, and improve bioavailability. By adding the medication to a film made of Hydroxy Propyl Methyl Cellulose, Polyethylene Glycol (PEG400), Sodium Starch Glycolate, glycerin, etc., using the solvent casting process, the rate of dissolution can be increased. The physicochemical characteristics of the films, such as disintegration time, surface pH, thickness, weight, percentage moisture absorption, folding endurance, drug content, and stability tests, were assessed. The solubility of the drug increased more by using Polyethylene Glycol 400 than Propylene Glycol and Isopropyl Alcohol; the release rate indicates that adequate concentration of Hydroxy Propyl Methyl Cellulose, Polyethylene Glycol 400 and the solvent evaporation method gave good results.