The aim of this study was to formulate and develop a sustained-release tablet of repaglinide using natural occurring binders to enhance its therapeutic efficacy and improve patient compliance. The selected antidiabetic drug repaglinide was used for preformulation study. In preformulation study of antidiabetic repaglinide drug was studied by using Physical appearance, Melting point method, solubility, pH and Flow properties. The developed matrix tablets were evaluated with number of parameters.