The goal of this study was to create and assess a polyherbal anti inflammatory cream that contained C. alata, C. tora, and C. dactylon extracts. Using carrageenan and formalin induced rat paw edoema models, the cream formulations were made using varied extract concentrations and tested for their anti inflammatory efficacy. The outcomes demonstrated that the polyherbal cream had more anti inflammatory action and a synergistic impact than individual formulations of the plant extracts. The combination formulation shown action comparable to that of the common medication diclofenac gel in the formalin induced rat paw edoema model, whereas the 4% C. alata gel formulation demonstrated the best suppression of paw edoema in the carrageenan induced rat paw edoema model. According to the study's findings, a cream made of multiple herbal anti inflammatory ingredients might be a good option for the treatment of local inflammation.