The aim of the present work is to formulate and evaluate Repaglinide nanoparticulated gel for topical delivery to reduce blood glucose levels by stimulating endogenous insulin production as a result of decreasing the side effects of Repaglinide by administering the drug topically and to increase the bioavailability of Repaglinide by converting in to nanoparticles. Minimizing the drawback of long term use of Repaglinide by converting in to nanoparticles by solvent/Antisolvent precipitation method and converting in to gel. The prepared nanoparticles will be evaluated for various characterization parameter such asParticle Size Analysis,Zeta potential, FTIR study, Differential Scanning Calorimetry (DSC), Surface Morphology (SEM)Further they are converted in to topical gel by using carbopol 934, HPMC. Evaluation parameters of gel Measurement of PH, Drug content, viscosity study, spreadability, extrudability, homogeneity, grittiness, In-vitro diffusion studies, stability. The formulated topical gel containing Repaglinide nanoparticals can be successfully used to increase the bioavailability of drug and to overcome the side effects