The current work involves preparation and evaluation of self-micro emulsifying drug delivery system of carvedilol, a nonselective beta blocker and alpha-1 blocker. Oral self-micro-emulsifying drug delivery system of Carvedilol were prepared by studying the solubility in different oils, surfactants and co-surfactants and formulations were prepared using mixtures of oils, surfactants, and cosurfactants in various proportions. Based on the solubility study, the optimized self-micro-emulsifying drug delivery system of carvedilol was prepared using Acrysol El 135 as oil phase and tween 20 and transcutol P as surfactant and co-surfactant, respectively. SMEDDS of Carvidilol were prepared with good self-emulsification efficiency and having globule size in nanometric range which may be physiologically stable. The optimized formulation consisting of Carvidilol (20mg), Capmul MCM (14.40%w/w), Tween 80 (27.20% w/w) and Propylene glycol (54.40% w/w) exhibited faster release profiles with a rapid rate of emulsification. The optimized SMEDDS formulation of Carvidilol showed a significant increase in oral absorption compared to the marketed product. The exposure (Cmax and AUClast) of developed SMEDDS was found to be comparatively higher (1.54 fold) than reference marketed product indicating better rate and extent of absorption than reference formulation