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ISSN 2063-5346
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FORMULATION AND EVALUATION OF SYNERGISTIC ANTIDIABETIC ACTIVITY OF WITHANIA COAGULANS DUNAL AND HIBISCUS ROSA SINESIS

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Kokate Bhakti1*, Maniyar Mithun2, More Vrunal3, Kokate Priti4
» doi: 10.48047/ecb/2023.12.si10.00305

Abstract

Hyperglycaemia is characterized by elevated blood glucose levels, stands as the most prevalent metabolic endocrine disorder. It is the chronic condition, caused due to the improper insulin production in body or due to insulin resistance, high blood glucose level and low blood glucose level leads to diabetic condition. The aim of the present research study was to formulate and evaluate poly herbal anti -diabetic tablet for medicinal purpose. The polyherbal tablets of Withania coagulans dunal and Hibiscus rosa-sinensis were prepared as side effects free, safer, cheaper and much effective medicine Granules prepared by wet granulation method, were performed preformulation studies based on the preformulation studies powder flow properties are good and Weight variation of F3 and F7was ±1.99 and ± 2.13 respectively, Hardness of F3 and F7 was 4.1± 0.01 kg/cm2 and 4.2± 0.03 kg/cm2 respectively, Friability of F3 and F7 are 0.73 ± 0.01% and 0.69 ± 0.01% respectively. Thickness of F3 and F7 was measured as 4.6± 0.02 mm and 4.4± 0.02 mm respectively, Disintegration time of both F3 and F7 are 15min15 sec good. The formulated tablets were subjected to in vitro release study and from which the formulation F7 was selected as optimized formulation which shows 91.68% drug release for Withania coagulans dunal and 81.88% drug release for Hibiscus rosa-sinensis.

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