The development and evaluation of an herbal anti-inflammatory gel employing a hydroethanolic extract from Tamarindus indica seeds is the current goal of our study. Methods: The gels were made with carbopol, various extract concentrations, propylene glycol, methylparaben, and the required volume of distilled water. Triethanolamine was gradually added to the gel, keeping the pH between 6.8 and 7.4. The produced compositions' physical characteristics, pH, spreadability, viscosity, and skin irritancy were evaluated. The anti-inflammatory activity was evaluated in albino Wistar rats of either sex (150-200 g) using a carrageenan-induced rat paw edema paradigm. The changed edema volume in the rat hind paw was calculated, along with the percentage of inhibition.