Purpose of this research work is to develop Gel for Topical drug delivery system for Antifungal effect. The preparation containing Fluconazole and Clindamycin was selected for preparation. The system delivers the drug at the specified time required by the patient to achieve maximum efficacy and improve drug efficacy with minimal side effects. Fluconazole is an imidazole derivative used for the treatment of local and systemic fungal infection. The oral use of fluconazole is not recommended as it has many side effects. Clindamycin is used primarily to treat anaerobic infections caused by susceptible anaerobic bacteria and having little effect. The present study was designed to formulate and evaluate different formulae of topical gel containing Fixed dose combination of fluconazole with Clindamycin mainly accelerate the anti-fungal effect by acting on fungus as well as reduce development of bacteria’s associated with that. The gel was formulated by using different polymers with different concentration as Carbopol 940, Hydroxypropyl methylcellulose E4M, Methyl cellulose, Pectin and Pluronic P407. Ten different formulae were prepared and characterized physically in term of color, syneresis, spreadability, pH, drug content and rheological properties. Drug-excipients compatibility studies were confirmed by carrying out DSC and FT-IR. In-vitro drug release in phosphate buffer pH 5.5 and permeation study through cellulose membrane, using a modified Franz diffusion cell, were performed. The results of In vitro drug release and its permeation studies showed that the highest values was from F3 (91.3% of drug released after 2 hr). The rheological behavior of the prepared formulae showed shear-thinning flow indicating structural breakdown of the existing intermolecular interactions between polymeric chains.