Background: The present research has been undertaken with the aim to develop a topical gel formulation of Propolis. Propolis is used for the treatment of local and systemic fungal infections. Commercially Propolis topical gel preparation is not available in the market, thus this formulation is made for better patient compliance and to reduce the dose of the drug, and to avoid negative effects such as liver and renal damage. Methods: The gel was formulated by changing the polymer ratio. Various formulations (F1, F2, F3, F4, F5, F6) were developed by using a suitable polymer (carbopol 934p and HPMC K4M). The formulation was evaluated for Drug Content, spreadability, pH, extrudability, viscosity, and in vitro drug release study. Results: Viscosity checks of various formulations revealed that formulation F4 outperformed the others. F4 performs better than all other formulations in terms of drug diffusion and Rheological characteristics. The pH of the F4 formulation is high enough to cure skin infections. The concentrations of Carbopol 934p and HPMC K4M in the gels were shown to have a substantial effect on drug release and rheological properties. Conclusion: It was concluded that formulation F4 was the best formulation among this formulation. As a result, formulation F4 should be further improved for industrial scale-up. Viscosity studies of various formulations revealed that formulation F4 was better compared to others. F4 performs better than all other formulations in terms of drug diffusion and Rheological characteristics. The pH of the F4 formulation is high enough to cure skin infections. The concentrations of Carbopol-934p and HPMC K4M in the gels were found to have a substantial effect on drug release and rheological properties.