Aim: Voriconazole has been a more potent antifungal activity but this has some grade of medical application due to low solubility issue. The goal of the current work was to development of Voriconazole nanoemulgel, to improve aqueous solubility of drugs across the nail used for the treatment of onychomycosis. Method: Aqueous titration method was use to prepare voriconazole nanoemulgel by using olive as oil, Tween 80, and PEG 400 as used as a surfactant and co-surfactant respectively. Its homogenized under high pressure to minimize the particle size of emulsion. Vesicle size and drug contain were optimized by 2 level, 2 factor, Simple Lattice design and the optimized batch. Nanoemulgel was prepared by using, the gelling agent is Carbopol 934. Thioglycolic acid is used as a nail penetration enhancer. Result: Drug polymer compatibility study show that drug and excipient are compatible with each other. A nanoemulgel study of in vitro drug release revealed improved drug release, i.e. that is 68% in 8th hrs. Thus more than 90% of drug release will happen in 24th hrs. which shows good release. Zone of inhibition of optimized batch was found to be 9.8mm.