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ISSN 2063-5346
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FORMULATION AND IN-VITRO CHARACTERIZATION OF SWERTIA CHIRATA EMULGEL FOR TOPICAL USE

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Prince Kumar Saini1*, Mukesh Kumar2, Shamim3, Prabhakar Vishvakarma4
» doi: 10.48047/ecb/2023.12.si10.00307

Abstract

Previous studies suggests that emulgel of Swertia chirata leaves extract has not been formulated yet. So, the present study is focused on the formulation and estimation of Swertia chirata emulgel for topical use. The fresh leaves of Swertia chirata were collected from the local region in western Uttar Pradesh. It was identified and authenticated by a botanist with specimen no. NBRI/PA/2022/12/0027. The powder of Swertia chirata was weighed and extracted through Soxhlet apparatus using ethyl alcohol. The preformulation study was performed for the extract in terms of solubility, and extract-excipient compatibility studies. The gel and emulsion were separately prepared then added together to get the Emulgel. Various physical examinations i.e., pH determination, swelling index, drug content estimation, spreadability, and in-vitro drug release were carried out. In results, preformulation study showed that Swertia chirata is well compatible to the different polymers used in the formulation of emulgel. Among all 3 preparations of emulgels, formulation F1 was found excellent in terms of pH range, viscosity, % drug release, swelling index, spreadibility and in-vitro drug release. However, physical appearance was found same as brown, translucent for all the emulgels (F1-F3). In conclusion, Swertia chirata emulgel F1 is one of the best compatible emulgel formulations with optimum characteristics. It suggests the isolation of active moieties and develop the optimized emulgels for different topical pharmacological uses.

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