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ISSN 2063-5346
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FORMULATION AND IN VITRO EVALUATION OF BILAYER TABLETS

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Sneha S.Marlapalle, Dr.Mrunal k.Shirsat, Dr.Santosh R.Tarke, Naresh R. Jaiswal, Ankalesha S. Gopalghare
» doi: 10.48047/ecb/2023.12.si8.468

Abstract

According to the study , the Formulation of bilayer tablets are suitable for constant release of two drugs in which one layer is immediate release layer and the second layer as extended release layer . Bilayer tablets have been developed to achieve immediate and extended delivery of different drugs with pre-defined release profiles. In the previous 10 years from today, interested in to design or formulate a combination of two or more active pharmaceutical ingredients (API) in a single fixed dosage form has increased in the pharmaceutical industry, promoting patient convenience and compliance1 . Bilayer tablet is suitable for sequential release of two drugs in combination or to incorporate of two incompatible substances in same tablet. Bilayer Tablets were prepared by using different grades of HPMC ( HPMC K4M and HPMC K 100 M) for extended layer and use of different super disintegrants ( Sodium Starch glycolate and PVP K-30 ) for immediate layer. Tablets were evaluated for physico chemical properties such as hardness, friability , thickness , weight variation and drug- content uniformity. FTIR studies revealed that there was no interaction between the drug and polymers used in study. In vitro drug release studies were performed using USP type II paddle type apparatus. The formulation gave an initial burst effect of immediate layer within half an hour and followed by extended release of drug for 12 hrs. The optimized formulations shows no significant changes on stability studies when stored at 40ºC /70% RH, for 3 months

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