The drug prazosin hydrochloride as an example, the goal of this work was to prepare and perform test invitro floating tablets of polyvinyl pyrrolidone (PVP) and hydroxypropyl methyl cellulose (HPMC). The floating pills were created using the effervescent technique, which employed sodium bicarbonate as a gas generator. The dry granulation process was used to create the tablets. The impact of HPMC's polymer concentrations and viscosity classes on the release profile of the medication was assessed. The effects of stearic acid and sodium bicarbonate on the floating properties and drug release profile were also investigated. According to in vitro dissolving research findings, raising the concentration of HPMC PVP and MCC may make it possible to preserve the pharmacokinetic profile. Combining sodium bicarbonate and stearic acid had no discernible impact on the medication release profile. The formulations with 20 mg of sodium bicarbonate per tablet showed the anticipated buoyancy, with an overall floating time of more than 24 hours, a floating lag time of around two minutes. The current work shows that prolonged-release floating tablets containing prazosin hydrochloride can be made using polymers such as HPMC, PVP, and MCC coupled as a gas-producing agent with sodium bicarbonate.