Diabetes mellitus is indeed a common endocrine disorder characterized by high blood sugar levels (hyperglycemia) due to problems with insulin production, insulin action, or both. It can lead to various complications and is a significant cause of morbidity and mortality worldwide. While traditional medicines from various cultures often suggest natural remedies for preventing and managing diabetes, it's important to approach these remedies with caution and in conjunction with evidence-based medical care. The present study aims to demonstrate the potential anti-diabetic effects of ethanolic extracts of Punica granatum and Coriandrum sativum in a rat model of STZ-induced diabetes and analyze the new polyherbal formulation. This type of research is often conducted to evaluate the potential therapeutic benefits of natural compounds on diabetes, and it typically involves various molecular and biochemical analyses. In this Group 4, treated with a specific ratio of the extracts, showed the most promising results, although glibenclamide remains the most effective treatment among all the groups tested. The therapeutic effectiveness in the test groups seems to be dosage-dependent. These findings provide valuable insights into the potential use of these plant extracts for managing diabetes.