The goal of this study was to develop a mucoadhesive buccal patch containing curcumin, lycopene, and quercetin for targeted administration in oral cancer. Buccal patches were made using ethocel and methocel polymers and the solvent casting process. Buccal patches were evaluated by disintegration time, folding endurance, % drug release, surface pH study, swelling study, mucoadhesive strength and stability studies. The developed patches were evaluated for cytotoxicity in KB cell line using MTT assay. Folding endurance of formulation was found to be 217.33. Formulation disintegration time was observed to be 6.51 minutes. As a result, it may be concluded that perhaps the developed buccal patch formulation could be a novel treatment for oral cancer