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ISSN 2063-5346
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FORMULATION AND INVITRO-EVALUATION OF PROPRANOLOL HYDROCHLORIDE SUPERPOROUS HYDROGELS

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Narappa Reddy.K.V, Rajasekaran.S
» doi: 10.48047/ecb/2023.12.si10.007

Abstract

Hypertension can be described as a continuous rise in blood pressure above than 120/80 mm Hg. A measure that represents number of patients can be differentiated according to a scale whose possibilities of hypertension associated to cardiovascular disease is sufficient more for merit medical intervention. Propranolol hydrochloride is a medication that belongs to a class of drugs called beta-blockers. Its main specialty lies in its ability to block the effects of adrenaline on the heart and blood vessels, thereby reducing blood pressure, heart rate, and the workload on the heart. One of the unique features of Propranolol Hydrochloride is its ability to cross the blood-brain barrier, which allows it to effectively reduce symptoms of anxiety, such as trembling, sweating, and rapid heartbeat. It has been found to be particularly effective in treating anxiety related to public speaking, social anxiety disorder, and post-traumatic stress disorder (PTSD). Superporous hydrogel were synthesized by using gas blowing technique. Acrylamide and acrylic acid were used as hydrophillic monomers; bisacrylamide (BIS) as a cross linker, distilled deionized water and pluronic F-127 as a foam stabilizer were included in the composition of SPH. SPH of Propranolol Hydrochloride showed good pre-compressional and post-compressional properties, Compatibility studies proved the integrity of the developed tablets. Stability studies indicated that optimized formulation is stable. Thus, the superporous hydrogel of Propranolol Hydrochloride have been successfully prepared to enhance bioavailability of the drug.

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