Natural polymers remain attractive primarily because they are natural products of plants, readily available, inexpensive and capable of multitude of chemical modification. Leaves of Hibiscus rosa-sinensis Linn (family: Malvaceae) contains high proportion of mucilage which can be used as additives in pharmaceutical formulations. The present work is to formulate and to optimize novel fast dissolving tablet containing Ketorolac Tromethamine using natural disintegrants isolated from Hibiscus rosa- sinensis leaves and its efficiency was compared with synthetic superdisintegrants like crosspovidone. Hibiscus rosa-sinensis mucilage was isolated and characterised for its identification by chemical test and micrometric properties. Fast dissolving tablets of ketorolac Tromethamine is going to be formulated by direct compression method using Hibiscus rosa-sinensis as super disintegrating, mouth freshener and compressibility and aspartame as sweetener. The tablets which are going to formulate were evaluated for their pre and post compression parameters like tablet hardness, thickness, % friability, wetting time they should be permissible limits.