In this present approach we have created candesartan and simvastatin gastro-retentive medication delivery system for the efficient control of hypertension. A prodrug having antihypertensive action, candesartan is a synthetic angiotensin II receptor antagonist produced from benzimidazole. The HMG-CoA reductase inhibitor pharmacological class includes the simvastatin drug. This is used to decrease triglycerides and bad cholesterol in the blood, such as low-density lipoprotein (LDL). A controlled release device in the form of floating microspheres was created to obtain the ideal therapeutic medication level over an extended period of time. By employing various concentrations of ethyl cellulose, HPMC, and chitosan and using the emulsion solvent evaporation method, floating microspheres containing candesartan and simvastatin were created. Three batches were prepared for every formulation for the purpose of assessing reproducibility in respect of % yield, entrapment efficiency, particle size, % buoyancy and % drug release. For candesartan and simvastatin, the average particle size was determined to be between 65.66 and 105.28 m and 49.94 and 93.1 μm, respectively. Percent drug loading efficiency of microspheres was found in the range of 58.36 to 93.08% for candesartan & 54.85 to 83.64 % for simvastatin. For candesartan and simvastatin, the percentage yield of microspheres for all formulations ranged from 43.68% to 98.32% and 56.32% to 78.65%, respectively. Optimized microsphere of candesartan and simvastatin showed 80.63 and 89.98 % buoyancy. Optimized formulation of candesartan and Simvastatin showed sustained release of drug and release 62.34 % of drug till 12 th hour where as simvastatin microsphere showed 64.35 % release after 12 th hour.