Transdermal drug delivery systems have many benefits, due to this, lot of interest has increased in this field nowadays. Main objective of this project is to create a Ocimum sanctum (Tulsi) transdermal patch. Ocimum sanctum is a very well-known medicinal plant with lot of therapeutic benefits. Investigating Ocimum sanctum's potential for controlled transdermal administration of bioactive substances is the goal of this research. The formulation development process involves choosing the best polymers, plasticizers, and permeation enhancers to maximize the physicochemical qualities of the transdermal patch and the drug release characteristics.