:The objective of present investigation study was carried out to modulate the release rate and reduce the dosage frequency of celecoxib, because frequency of doses causes ulcer in stomach, bleeding, holes in the stomach or intestine. When doses increase consumption of additives also increase. To minimize the side effect and for getting prolonged effect the study was carried out. In this study hydrophilic and hydrophobic polymers are used for making this formulation. Since celecoxib is freely soluble in alkaline aqueous solution hydrophilic polymers alone cannot retard the rate of release. So hydrophobic polymer Eudragit RL 100 is selected. HPMC used as a hydrophilic polymer. This controlled release tablets were prepared by direct compression technique. The pre-compressed powder blend was evaluated for various parameters like angle of repose, compressibility index and Hausner’s ratio. So all the parameters were suitable for direct compression. Then the prepared matrix tablets were evaluated for hardness, thickness, friability, weight variation, drug content and invitro release. Dissolution studies revealed that optimized formulation (F5), release the drug up to 24 hours in controlled manner