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ISSN 2063-5346
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FORMULATION DEVELOPMENT AND CHARACTERIZATION OF OLMESARTAN MICROBALOONS

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Dr.Ravi Kumar Kota1*, Sher Vani2 , P. Meghana3 , Arigala Gayatri Devi4 , D.Priyadarshini
» doi: 10.48047/ecb/2023.12.si5a.0410

Abstract

The objective of the current study was to increase the bioavailability of olmesartan (OLM) by using gastro retentive formulations to keep the drug in the gastrointestinal tract (GIT) for a longer period of time, enhance drug release, and increase efficacy. As rate-controlling polymers, EC and hydrophilic polymer HPMC are utilized in the solvent diffusion process to formulate Microbaloons. The drug's embedding in the Microbaloons' shell and attainment of surface smoothness were discovered and validated by SEM examination. A modest particle size of less than 117µm may have contributed to the prepared Micoballoons' for excellent floating characteristics over a period of more than 12 hours. In-vitro drug release was performed using the USP Type-I method in 0.1N HCL drug released obtained 69.5 % for 12 hours for optimal formulation which may be attributed for effective entrapment efficiency for the prepared formulations. Kinetic studies reveals that higher values of correlation co-efficient obtained through Higuchi square root of time, indicates diffusion mechanism. The optimized formulation was best fitted with kores Myer papas model of n value 0.5 indicates anomalous drug transport.

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