Topical drug administration is a localized method of delivering drugs to specific areas of the body via topical channels such as ophthalmic, rectal, vaginal, and cutaneous. The major route of topical medication delivery is through the skin, which is one of the most easily accessible organs on the human body for topical drug administration. The present investigation involves formulation of topical Nanofibrous gel using Ketoconazole and Clotrimazole. For the treatment of fungal Infection, Topical Ketoconazole and Clotrimazole is used to treat Fungal Infection. Ketoconazole and Clotrimazole belongs to the antifungal family of drugs. It works by reducing fungal infection. Topical Nanofibrous gel of Ketoconazole and Clotrimazole was prepared by using High molecular weight water soluble polymer Hydroxy propyl methyl cellulose such as K35 grade and other excipients including carbopol, methyl paraben, Glycerin and purified water were reported in the formation of Nanofibours gel. In the present investigation combination of Ketoconazole and Clotrimazole Nanofibrous gel.The formulated gel was evaluated for pH, viscosity, Spreadability, extrudability, conductivity, particle size, zeta potential, in vitro drug diffusion studies. Among the formulated gel batch 3 has met all the specifications and was formed to be optimized Efficient delivery of drug to skin application was found to be highly beneficial in localizing the drug to desired site in the skin and reduced side effects associated with conventional treatment.