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ISSN 2063-5346
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Formulation Development and Evaluation of a Topical Nanogel Containing Kojic acid

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Borase Pallavi S, Dr. Barge Vijaya , Dr. Kasabe Amit , Gaikwad Rajratna , Avhad Pratiksha , Deshmane Kamlesh
» doi: 10.48047/ecb/2023.12.si8.287

Abstract

Topical drug administration is a localized method of delivering drugs to specific areas of the body via topical channels. The major route of topical medication delivery is through the skin, which is one of the most easily accessible organs on the human body for topical drug administration. The present investigation involves formulation of topical nanogel using Kojic acid for the treatment of hyperpigmentation, Kojic acid is an effective and well tolerated drug having melanin neutralising activity (Tyrosinase inhibitor). Topical nanogel of Kojic acid was prepared by using High molecular weight water soluble polymer Hydroxy propyl methyl cellulose such as K35M grade and other excipients including methyl paraben, Carbopol 940, glycerine and purified water were reported in the formation of nanogel. In the present investigation nanogel the formulated nanogel was evaluated for pH, viscosity, Spreadability, extrudability, conductivity, particle size, zeta potential, in vitro drug diffusion studies. Among the formulated nanogel batch 4 has met all the specifications and was formed to be optimized Efficient delivery of drug to skin application was found to be highly beneficial in localizing the drug to desired site in the skin.

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