In the development of mucoadhesive tablet of antifungal drug Posaconazole to treat oral thrush locally β-cyclodextrin used as hydrophilic matrix to improve the solubility. Posaconazole is poorly water soluble drug hence β-Cyclodextrin was used to improve the solubility and bioavailability of drug, simultaneously enhances the erosion rate of tablet. Which increases the drug release and permeation through buccal mucosa? The formation of inclusion complex of Posaconazole with β-Cyclodextrin was confirmed by phase solubility studies. Co-precipitation method was used to prepare inclusion complex of Posaconazole with β-cyclodextrin. The inclusion complex was characterized for compatibility studies. The results of compatibility studies reveal the successful complexation between Posaconazole and β-cyclodextrin. Mucoadhesive tablets of Posaconazole were prepared by direct compression method using altered concentrations of HPMC K4, Carbopol 934P and Maltose as polymers and Chitosan Polymer also used to enhance solubility. From the results concluded increase amount of polymers decreases the drug release at controlled rate. Formulation F6 was proved to most promising with the drug release time of 8hours 98.96%. Formulation F6 was subjected to stability testing at 45℃ & 75% RH and there is no significant change Observed. The outcome of the projected work is to designed mucoadhesive tablet of Posaconazole for controlled release in buccal mucosa. Posaconazole was chosen based on its indication for the treatment of oral Candidiasis refractory to other triazole derivatives