Nicardipine is a calcium channel blockers which blocks the influx of calcium ions into smooth muscles and blocking the influx of calcium ions which results in a vasodilation and decrease the oxygen consumption and reduce the cardiac load. Nicardipine is used in the treatment of hypertension and angina pectoris and also used for management of heart failure. Aim of the present work is to formulation and evaluation of mucoadhesivetablets of Nicardipine using natural binders such as Gum tragacanth and Guar Gum to reduce the first passmetabolismandfrequencyofadministration. HPMC was used as polymer Gum tragacanth and Guar Gum used as swelling agent as well as control release polymer. The tablets were formulated bydirectcompressionmethodandwerethenevaluatedforvariouspre-compressionandpostcompressionparameterssuchashardness,friability,thickness,weightuniformity,drugcontent,drug release, swelling study, in-vitro drug release and in-vitro mucoadhesive strength. FTIR showedno interaction between drug and polymers.