Objective: To formulate and evaluate Sea buckthorn (Hippophae Rhamnoides) extract loaded oral herbal gels. Materials and Methods: Oral herbal gels were formulated incorporating the extracts of Hippophae rhamnoides using carbopol 934 and carbopol 940 as the gelling agent. Eight batches were formulated by varying the concentration of the extract and gelling agent (F1 to F8). The prepared formulations were evaluated for various parameters like physical appearance, pH, spreadability, viscosity, homogeneity, invitro release profile and antimicrobial activity against fungi and bacteria. The antimicrobial activity was also compared with a marketed gel formulation