The present study aims was at developing Levamisole controlled release tablets. Levamisole is anti-helminthic drug that is usually used for treatment of infections caused by parasites i.e., worms. Levamisole showed maximum absorption at wavelength 224nm in 0.1N HCL and 226nm in pH 6.8. The Drug - polymer compatibility studies conducted by FTIR provided required confirmation about their purity and indicated that there is no interaction between the drug and selected polymers. Various formulations were developed by using release rate controlling forming polymers like HPMC K100M, Eudragit RS PO and Ethyl cellulose by direct compression method. From among all the developed formulations F5 formulation controlled the drug release for longer period when compared to other formulations; So F5 was selected as the best formulation. From the research study conducted and from the release kinetics graphical profiles it was concluded and established that drug release from the optimized formulation followed Zero order release kinetics, which was specified by correlation coefficient - R2 value that was higher for Zero order release. So the drug release mechanism is considered to follow controlled release system.