The aim of the present study was to formulate, optimize and evaluate the solid self-emulsifying drug delivery systems (S-SEDDS) of Bictegravir Sodium by use of factorial designs to enhance the oral absorption of Bictegravir Sodium by improving its solubility, dissolution rate, and diffusion profile. SEDDS are the isotropic mixtures of oil, surfactant, co-surfactant and drug that form oil in water microemulsion when introduced into the aqueous phase under gentle agitation. Solubility of Bictegravir Sodium in different oils, surfactants, and cosurfactants was determined for the screening of excipients. Formulations were developed based on the optimum excipient combinations with the help of data obtained through the maximum micro emulsion region containing combinations of oil, surfactant, and co-surfactant. The optimum formulation of L-SEDDS contains Capmul MCM (16.58 mg/ml) was selected among the screened vehicles as an oil system with the highest solubilisation potential. As surfactants, PEG 400 was used as surfactants in about 80 (13.25 mg/ml) and Polyethylene glycol (17.48 mg/ml). Adsorbents including aerosil 200 and Neusilin US2 have been used in the optimised liquid SEDDS formulation (F12). Drop wise to the solid, adsorbent, and blended in a mortar and stick, optimized liquid SEDDS. The S-SEDDS was evaluated for different parameters. Overall, this study suggests that the dissolution and oral bioavailability of Bictegravir Sodium could be improved by S-SEDDS technology.