This study presents the formulation, evaluation, and in vitro drug release of Miconazole Microemulgels as a potential antimicrobial therapeutic agent. Three formulations were prepared, each utilizing a different base material: Hydroxypropyl Methylcellulose (HPMC), Carbopol 934, and Carbopol 940. These novel drug delivery systems aim to combine the benefits of microemulsions and gels, including enhanced solubility of hydrophobic drugs, improved drug stability, and ease of application. Several physicochemical properties of the microemulgels were analyzed, such as pH, viscosity, spreadability, and extrudability. Furthermore, the drug release profiles were examined over a 12-hour period. The HPMC Microemulgel demonstrated the highest drug release, smallest particle size, and most negative zeta potential, indicating its potential for enhanced drug delivery efficiency and stability. Despite promising in vitro results, further research, including in vivo studies, is recommended to validate these findings and to assess the therapeutic efficacy and safety profile of these Miconazole Microemulgels.