The primary objective is to produce sertaconazole nitrate emulgel to enhance the topical release of the drug via Carbopol 934P. Different types and amounts of gelling agent, surfactant, and oil (stearyl alcohol) were used to investigate the drug release. The manufactured emulgels were evaluated for their appearance, pH, viscosity, spreadability, extrudability, in vitro and in vivo drug release, and stability. Observations were discovered to fall within the acceptable range. The in-vitro release rate was measured using a diffusion cell with a dialysis membrane and phosphate buffer pH 7.4 as a medium. Box-Behnken design was used to optimise the system. Ex-vivo studies revealed that the EM (overlay plot) containing Carbopol 934P (1.8%), surfactant (2.62%), and oil (10%) released the least quantity of drug, 12.3%.