The transdermal patch provides safe as well as effective drug delivery and also gives the patient compliance. Compatibility studies of the Curcumin and natural polymer were carried out. The transdermal patch was prepared by solvent casting method. Initially preliminary trials were carried out for the selection of excipients and their relative quantity in the dosage form. In the present work, the Curcumin patch of different concentration of natural polymer pectin were prepared and evaluated for specific parameters such as folding endurance, thickness, weight variation, diffusion studies. The drug release was carried out for 360 minutes. Identification and compatibility study of drug and excipients were carried out using Melting Point, FTIR studies. The evaluation parameters were found out to be within Pharmacopeia standards. Optimized batch 3 shows % drug release at 360 min. (87.19%). It can be concluded that the present controlled release patch can be an ideal system to improve bioavailability and Curcumin directly disseminated in systemic circulation. The Curcumin patch prepared from natural pectin is a promising future aspect for novel drug delivery system and which minimize the side effects of the conventional allopathic drugs.